The Upper Perkiomen Valley Chamber of Commerce is a member-based, business advocacy organization striving to serve nearly 300 members by providing vision and leadership to foster economic vitality and to enrich the quality of life in the Upper Perkiomen Valley. ​

The Chamber defines its service area as the Upper Perkiomen School district, which includes four boroughs (East Greenville, Green Lane, Pennsburg, and Red Hill) and three townships, (Marlborough and Upper Hanover in Montgomery County, and Hereford in Berks County).